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Others suggest an age-related chronobiological hypothesis that emphasizes the importance of the circadian system and the deterioration with age [5], and others have defended the loss of function hypothesis and the indirect effect of melatonin on glucose metabolism through its role on the central biological clock [2]

MT-1 (Afamelanotide) has been studied and approved in some countries for the treatment of erythropoietic protoporphyria (EPP), a rare disorder that causes severe sensitivity to light