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J Biol Chem 294:10451058 Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y (2014) Concomitant accumulation of alpha-synuclein and TDP-43 in a patient with corticobasal degeneration

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While Cys-SOH and the disulfide can be reversibly reduced to Cys-SH via the use of either physiological reductants or enzymatic reactions, Cys-SO 2 H and Cys-SO 3 H generally cannot be reduced back to Cys-SH via biological systems [40]