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Maki et al., 2005), as well as essential for normal physiological and cellular properties, such as sprouting angiogenesis of endothelial cells (Lucero and Kagan, 2006

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The ANLS hypothesis proposes a coherent model where glutamate uptake by astrocytes stimulates their glycolysis, leading to lactate production and export, which is then taken up and oxidatively metabolized by neurons to meet activity-dependent energy demands (Brooks, 2018