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Description
anyone can develop a deficiency of vitamin B12, some population groups suffer more easily

Elevated cAMP levels are believed to possibly activate protein kinase A (PKA), a molecule that appears integral to intracellular signaling

High homocysteine levels impair the function of blood vessels and raise the risk of a heart attack and a stroke

Some insurers require documented trial of oral supplementation before approving injections, though this contradicts the pathophysiology-patients with true intrinsic factor deficiency cannot absorb oral B12 regardless of dose
