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Although the overall safety of IV GSH, extrapolated from studies evaluating its use for male infertility and liver disorders seems to be convincing [18,19], several adverse effects of IV GSH have been documented in the Philippines (Figure 2), detailed in the position paper by the FDA, Department of Health, Republic of the Philippines [5] with a warning for the public on the subject of the safety of the off-label use of glutathione solution for injection (Figure 3)

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Porphyromonas gingivalis promotes atherosclerosis by inducing endothelial apoptosis