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Ifosfamide is an structural analogue of cyclophosphamide that is widely used antineoplastic agent in various malignancies such as breast cancer, non-small cell lung cancer, soft tissue sarcomas but its effectiveness has been compromised by its nephrotoxicity.7881 It is a prodrug that is metabolized into active but toxic metabolite chloracetaldehyde (CAA) in order to produce its pharmacological antitumor effect.82 Ifosfamide conversion into nephrotoxic chloracetaldehyde (CAA), mainly in renal proximal tubules, results into renal dysfunction that is associated with oxidative stress and impaired tubular transporters functions which is most commonly presented as Fanconi's syndrome.8385 Sener et al

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The laser stimulates fibroblasts which are responsible for the production of collagen and elastin in the body

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