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This study showed for the first time that insulin effects on all levels of the vascular tree are impaired in patients with insulin resistance

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M

doi:10.1016/S0076-6879(97)81036-1

Notably, the incidence of cholangiocarcinoma is substantially higher among patients with UC than in the general population (OR = 7.67
