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A large observational study of over 20,000 participants found an inverse relationship between OA and omega-3, in which consuming a larger amount of omega-3 was associated with a reduced prevalence of OA [81], suggesting a protective effect of high omega-3 consumption and development of OA
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Many compounds, such as fluoxetine, MCC950 and berberine, block depression by inhibiting the NLRP3 inflammasome [139]
