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DOI: 10.1111/j.1750-3639.2008.00186.x 83
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Following stress stimuli, the activation of NRF2 promotes a broad spectrum of downstream target genes involved in various cellular processes such as iron catabolism ( FTH1 , FTL ), metabolism ( G6PD , TKT ), antioxidant signaling ( TXN , GCLC , GCLM ), and xenobiotic transformation ( NQO1 ) [31]
