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Various pathological stimuli can lead to disruption or otherwise altered permeability and function of the BBB, such as ischemia, oxidative stress, and inflammation [226]
Lastly, in treating other diseases, modulating NRF2 deubiquitination in skin macrophages affects pain perception[126] (Table 4)
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Clinical data showed reductions in oxidative stress markers and inflammation alongside preserved bone density [23]
