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A review of the evidence for a protective role of uric acid in Parkinsons disease

6.1 Glutathione metabolism: modern view of biosynthetic pathways, NADPH dependence, and relationship to thioredoxin The synthesis of glutathione (GSH) predominantly occurs through the ATP-dependent -glutamyl cycle, beginning with the action of glutamate-cysteine ligase (GCL), the key rate-limiting enzyme composed of two subunits: a catalytic component (GCLC) and a regulatory modifier (GCLM)

However, methylation at certain histone sites can promote gene expression (see methylation or acetylation of histones Figure 2 )

A systematic review by Lee et al