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Ralph Carmel, one of the modern scientists who has studied B12 most thoroughly, comments in one of his studies: Most of the newly recognized deficiency is subclinical in nature, with an uncertain impact on health. The prevalence has increased with the inclusion of people with normal B12 levels, some of whom are deficient. Folic acid fortification of some products/foods has raised concerns about the potential adverse neurological consequences of folate in people with undetected B12 deficiency. NOTE: Deficiency IS NOT THE SAME AS symptoms (there may be temporary asymptomatic deficiency) and the onset of symptoms is variable and interindividual

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Aquilano K., Baldelli S., La Barbera L., Lettieri Barbato D., Tatulli G., Ciriolo M.R

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Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis