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Moreover, increased levels of LCACs may also induce endoplasmic reticulum (ER) stress and accelerate the progression of cell damage [30]

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Besides a diagnosis of NF1, the other primary known risk factor for MPNST development is radiation exposure, typically in the context of a secondary malignant neoplasm occurring following radiotherapy [22]

After extracting single cells from skin fragments, melanocytes cultured for 34 weeks are transplanted into the recipients skin