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Ethics declarations Competing interests All authors are employees of The Institute of Cancer Research, which has a commercial interest in abiraterone acetate

Circ Res 121(9):1024-6 2017 PMC5679459 Wall VZ, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Pennathur S, Bolego C, Ellis JM, Gijn MA, Wolfgang MJ, Bornfeldt KE

In insulin-resistant states, the liver continues to promote lipid synthesis but fails to suppress glucose production

However, another study suggests that the inhibitory function of PAI-1 on HSC mobilization is solely attributed to intracellular PAI-1 activity based on transwell migration assays and cell transplantation studies (547)