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Tamoxifen controlled expression of isoleucin to threonine substitution at codon 73 in Sftpc (I73T) results in misprocessed proSP-C and leads to increased mortality at day 7 to 14 and acute diffuse parenchymal lung injury with polycellular alveolitis

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However, some patients report sleep disturbances that may be indirectly related to gastrointestinal symptoms or metabolic changes during treatment

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