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Il est prsent dans tout notre corps, en particulier dans les organes vitaux tels que le foie, les reins et le cerveau

Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3

*Correspondence: Chen Chen, [email protected] Guo, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute