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In the Nature study, researchers demonstrated that levodopa reversed the effects of inflammation on the brains functional connectivity in reward circuitry and anhedonia (inability to feel pleasure) in depressed individuals with higher C-reactive protein (CRP), a blood biomarker produced and released by the liver in response to inflammation

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Inflammatory factors such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1) and lipopolysaccharide (LPS), as well as hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), high glucose, high salt and lead, can upregulate ESM1 (2426)

An ascending inhibitory myenteric pathway exists in the proximal colon, which was driven by nicotinic transmission