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Additional analyses using IPD and aggregate data Overall, additional analyses using both IPD and aggregate data were in agreement with the findings of the main analysis (online supplemental appendix 16)

by denervation of chronic use of a receptor antagonist)

There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant

proper site rotation minimizes this risk
