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In vivo, PNPLA2 is expressed in breast cancer cells and not in normal breast epithelial cells, and PNPLA2 expression is correlated with poor prognosis (211)

Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006

High homocysteine levels can also be caused by low vitamin B12 levels because vitamin B12 is the cofactor needed by the enzyme responsible for converting homocysteine to methionine
