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The estimated mean terminal half-life after a single subcutaneous administration of 0.12 mg/kg of mecasermin in paediatric subjects with severe primary IGFD is 5.8 h [116]
Kim I.J., Lee H.S., Ju H.J., Na J.Y., Oh H.W
[DOI] [PMC free article] [PubMed] [Google Scholar] 29.White JM, Delos SE, Brecher M, Schornberg K
This suggests a very good safety and tolerability profile indistinguishable from placebo in those trial settings
