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Dietary fat quality also has a significant influence, with unsaturated fats, particularly omega-3 fatty acids, exhibiting anti-inflammatory and insulin-sensitizing effects [19]
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The intricate metabolic microenvironment within the tumor, characterized by nutrient gradients, hypoxia, and interactions with stromal cells, adds another layer of complexity to the design and implementation of glutamine-targeted therapies [40,43,44,45,46]
