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The combination is safe and effective for Fitzpatrick III to V skin when the needle depth and session frequency are calibrated conservatively, and when the patient follows consistent sun protection

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The heating rate is also identified as an important factor because the HTL process is kinetically controlled ( Biological Depolymerization Biological depolymerization of lignin refers to the process of lignin degradation with the assistance of bacteria, fungi, or isolated enzymes under relatively mild conditions