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, Fassett, R

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Similar G1 arrest by 13-O-acetylsolstitialin A and Tetrandrine has been observed, both of which act on the cyclin D1-CDK4 complex: 13-O-acetylsolstitialin A decreases the expression of cyclin D1 and CDK4 156 , whereas Tetrandrine binds the cyclin D1-CDK4 complex and forms hydrogen bonds 157

A drop from 40% to 7.5% represents a major clinical improvement
