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PLoS One 9, e101668 (2014)

For example, microbiota-induced reductions in SCFAs and specific bile acids may weaken anti-inflammatory and analgesic mechanisms, whereas disturbances in tryptophan metabolism and other metabolic pathways may promote pain sensitivity and fatigue (105, 106)

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The common parlance of nutritional gaps is an oversimplification and does not take into account absorption challenges and depletion caused by factors other than lack of dietary consumption
