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The training process of RBF ANN can be considered as the optimization process of function center, spreading constant and connection weight, namely, c i , i , w i

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The peroxidation of cell membrane lipids, triggered by iron and the inactivation of antioxidant pathways, results in the accumulation of lipid peroxides and reactive oxygen species (ROS), causing cell membrane rupture and cell death

Moreover, HSV-1 infection enhances the E3 ubiquitin ligase Keap1 (Kelch-like ECH-related protein 1)-mediated ubiquitination and degradation of nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates the expression of antioxidative genes, thereby disturbing cellular redox homeostasis and promoting ferroptosis