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However, an (increased) eCATH-1 expression might occur only under particular conditions, e.g., after stimulation by microbial antigens

Furthermore, indirect data suggest that barrier defect might precede the onset of disease (316) and up to 40% of first-degree relatives of patients with Crohn's disease demonstrate an altered small intestinal permeability (317)

FIGURE 2 Anti-amnesic Effect of Embelin in Rats With Scopolamine-Induced Amnesia The NOR test showed a reduction in recognition index percentage for the negative group (SCP 1 mg/kg) in the chronic scopolamine model ( Figure 3A )