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doi: 10.1200/JCO.19.01740 364 ForniGLolliniPLMusianiPColomboMP

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Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease

a) Overlap of the 16/SjGST cocrystal structure (PDB: 8GYD, with compound 16 depicted in green, SjGST in blue, and key residues shown in a gray sticks) with the IBZGSH/SjGST structure (PDB: 1M9B, where IBZGSH is shown in magenta and SjGST is represented by orange lines)