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The authors used a random-effects model to pool the data

The researchers used Annexin-V FACS analysis and DNA laddering to demonstrate that Sag activated apoptosis in the sensitive cell lines in a dose- and time-dependent manner

But, more research is needed, as these studies were done at a chemical level and not through human clinical trials.59 Blackberry: More thorough research is needed on this ingredient, but one 2017 study suggests blackberry may decrease skin melanin and erythema (reddening).60 While these ingredients appear to be gentle enough for sensitive skin, they arent very well-researched as depigmenting agents and may not lead to ideal results for those with anything more than very mild hyperpigmentation

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