glutathione addiction Full article: as an oral whitening agent: A randomized, double-blind, placebo-controlled study Metabolic features of cancer cells
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Importantly, protein adducts on mitochondria are most critical for toxicity because they trigger initial oxidative stress, which is amplified through a mitogen-activated protein (MAP) kinase cascade with the ultimate activation of c-jun N-terminal kinase (JNK)

Hoeper MM, Kramer T, Pan Z, et al

B12 Intravenous Dose Considerations for Rapid Correction Intravenous Vitamin B12 is key for severe deficiency cases
[DOI] [PubMed] [Google Scholar] 219.Klok MD, Jakobsdottir S, Drent ML