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We demonstrated that in senescent vascular endothelial cells, FOXO4-DRI effectively disrupts the FOXO4-p53 interaction

doi: 10.1002/cam4.4395 32 ChenXYuCKangRKroemerGTangD

however, phosphorylation of c-Met by EGFR occurs without production of hepatocyte growth factor (HGF) or another secreted factor, supporting a ligand-independent mechanism

For first-line drugs, isoniazid (INH) resistance is primarily associated with mutations in the katG gene, which encodes the catalase-peroxidase enzyme responsible for activating INH (Rivire et al., 2020)
