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Description
This front-loading strategy aims to rapidly establish therapeutic tissue concentrations
Flow-Dependent Elimination In contrast to capacity-limited drug elimination, some drugs are cleared very readily by the organ of elimination, so that at any clinically realistic concentration of the drug, most of the drug in the blood perfusing the organ is eliminated on the first pass of the drug through it
Role of cytosolic 2-Cys Prx1 and Prx2 in redox signaling
Am J Physiol Heart Circ Physiol 2003
