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Among them, resveratrol and quercetin are strong activators of SIRT1 and PGC-1 signalling, enhancing mitochondrial resilience in metabolic stress conditions, while fisetin promotes effectivity of mitochondrial populations

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Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

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Sep 2012;46(3):152-7

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Vitamin C has anti-inflammatory and antioxidant effects that may be beneficial for people with lupus

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