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In addition to the Xc/GSH/GPX4 pathway, 2 additional pathways are recognized as major pathways in the ferroptosis system

43 One RCT evaluated B12 alongside anti-depressants in patients with depression and moderately low B12 status (190300 ng/l) and found that 100% of those on B12, 1000 g per week i.m

10.1186/S40035-019-0146-Z 117 RuschC.BekeM.TucciaroneL.DixonK.NievesC.MaiV.et al (2021)

Additionally, selenium, through its incorporation into selenoenzymes such as GPx and sperm capsular selenoproteins, protects membranes from oxidative damage and contributes to the structural architecture of mature sperm [72,78]