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Since acidosis is a hallmark of inflammatory processes as well as a crucial determinant of tumor progression, resulting from the increased glycolysis and the subsequent accumulation of lactic acid as well as the massive production of protons [83], glutamine supplementation may help to reduce inflammation in cancer cachexia patients by maintaining pH homeostasis in the body via ammonia (NH 3 ) transport between tissues [5,84]

Cancer Cell , 2023, 41: 13631380.e7 Corbet C, Feron O

In our study, significantly more SA--gal staining-positive cells were observed in PDL9 chondrocytes