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dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of pKa Values Span 60 Orders
Description
Antibody formation is a concern with any peptide therapy
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of pKa Values Span 60 Orders](https://cdn.masterorganicchemistry.com/wp-content/uploads/2019/11/1-pka-table-with-real-life-distance-analogy-in-meters-installed-1.gif)
In our trial, vitamin B-12supplemented mothers had higher blood vitamin B-12 concentrations during pregnancy but not significantly lower MMA or tHcy blood concentrations
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of pKa Values Span 60 Orders](https://www.researchgate.net/publication/8918738/figure/tbl5/AS:11431281127926369@1679225521642/Phenol-Substituents-and-Their-Observed-and-Predicted-pKa-Values-Obtained-at-Level-E-Using.png)
It can be difficult for patients to increase levels sufficiently through diet and supplements alone which is where vitamin injections come in
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of pKa Values Span 60 Orders](https://www.researchgate.net/publication/353881051/figure/tbl1/AS:1057423905275906@1629120913576/The-dissociation-constants-pKa-of-investigated-b-diketone-derivatives-in.png)
F.KellerS
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of pKa Values Span 60 Orders](https://figures.semanticscholar.org/29c478379cab59ca63fdd5cb5d52324686924518/4-Table1-1.png)