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Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota

In the mitochondrial matrix, tricarboxylic acid cycle (TCA) enzymes generate electron carriers such as NADH and FADH2, which donate electrons to the electron transport chain (ETC) in the IM

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In islet cells, the brain, and renal tubular cells, the reaction is directed primarily towards the oxidative deamination of glutamate because these cells and tissues contain high glutamate and low -KG/NH3 levels ( FIGURE 2 GDH aids in preserving the NH4 + concentration in the kidneys and several other organs (Treberg et al., 2010)