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Are there reasons to avoid B12 shots
In addition to its synergistic effects with TNF, IL-17 suppresses melanogenesis through ROS-dependent autophagic melanocyte apoptosis and stimulates keratinocytes to secrete IL-1 through the nuclear factor-B (NF-B)/ROS/ NLR Family Pyrin Domain Containing 3 (NLRP3)/caspase 1 pathway 152

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Figure 5: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study
