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61 Finally, the effector protein, typically a caspase enzyme, is recruited to the complex and activated, initiating downstream signaling events that lead to inflammation and cell death

Superoxide dismutase activity in the brain of experimental animals administered sweeteners [sucrose (15% and 30%), aspartame (3.5% and 7.0%), date (10% and 20%), erythritol (15% and 30%), and stevia (2.5% and 5.0%)]

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The 2023 renaming emphasizes metabolic causation rather than defining the disease by the absence of alcohol