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MN administration improved the bioavailability and therapeutic effect of 5-ALA-PDT in vivo To confirm whether our developed theranostic microneedle patch (MN-CCPCA) could effectively treat solid malignant tumors by optimizing the delivery strategies and complex parameters of 5-ALA-PDT, the biological distributions of PpIX after intravenous injection (i.v.), intratumoral injection (i.t.) or MN administration of 5-ALA and CCPCA were determined by FL imaging, respectively

Accepted 07 April 2024

PMID 23382217

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