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Funding This work was supported by the 2020 Basic Medical Research Fund of the Japanese Dermatological Association (donated by Shiseido) (YY)

Sustained Release: Subcutaneous tissue acts as a natural reservoir, providing gradual release and extended activity

For instance, NO, a critical factor for vasodilation, is synthesized by endothelial NO synthase (eNOS) within endothelial cells [179,180,181,182,183]

310 The kidneys susceptibility to oxidative stress stems from various sources including the mitochondrial respiratory complex, NADPH oxidases, endothelial nitric oxide synthase (eNOS), myeloperoxidase, and xanthine oxidoreductase (XOR), all of which contribute to the advancement of chronic kidney disease and its related complications