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On the other hand, large predatory fish (such as swordfish) tend to concentrate pollutants, particularly persistent organic pollutants, heavy metals, and microplastics, due to biomagnification and bioaccumulation

T.ShirachiD

Autophagy is divided into three subtypes (macroautophagy (herein referred to as autophagy), chaperone-mediated autophagy (CMA), and microautophagy), which can be nonselective or selective [5] and include the selective removal of damaged mitochondria by mitophagy and the selective removal of endoplasmic reticulum components by phagocytosis [3, 5,6,7]

This suggests that the endocrine system may play a role