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While the comproportionation reaction is a well reported redox cycling chemical mechanism, in this instance the triad model does not require the additional comproportionation reaction to accurately replicate the experimental OCR profile, suggesting that the comproportionation reaction is not mechanistically integral to the production of ROS through a quinone-based redox cycle

Abbreviations BBB: Blood-brain barrier BER: Berberine CS: Chitosan DMSO: Dimethyl sulfoxide EE %: Percentage entrapment efficiency GFAB: Glial fibrillary acid protein GSH: Reduced glutathione IHC: Immunohistochemistry MAO-B: Monoamine oxidase B MPTP/P: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine PDI: Polydispersity index PD: Parkinsons disease SOD: Superoxide dismutase TEM: Transmission electron microscopy TNF-: Tumor necrosis factor alpha References Cheng Z, Kang C, Che S, Su J, Sun Q, Ge T, Guo Y, Lv J, Sun Z, Yang W, Li B, Li X, Cui R

[DOI] [PubMed] [Google Scholar] 109.Holmay M.J., Terpstra M., Coles L.D., Mishra U., Ahlskog M., z G., Cloyd J.C., Tuite P.J

Furthermore, different microbes have variable susceptibility to the oxidative and non-oxidative anti-microbial mechanisms of neutrophils
