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Meta-analysis of these studies demonstrated (Figure 4) that there was no significant difference in the mean changes (follow-up from baseline) between groups (SMD, 0.006
Interestingly, in an in vivo AOM-induced murine CRC model, VSL#3 administration resulted in the upregulation of colonic TNF- compared to the untreated control group further suggesting a potential immunomodulatory role of VSL#3 linked to enhanced epithelial healing
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