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Even before the identification of the HD gene and the development of transgenic models, researchers primarily relied on excitotoxic lesions in the striatum to simulate HD in animal studies (Ramaswamy et al., 2007)

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2.2 Parkinson's disease (PD) PD patients show exhaustive gut microbiome dysbiosis, such as reduced Prevotella and increased Enterobacteriaceae, which can be related to GI symptoms such as constipation (Hashish and Salama, 2023)

(Singapore: Springer Nature), 141162
