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Scarce data are available on the molecular mechanisms of nephrotoxicity and the reasons for the specific proximal tubular sensitivity to the drug
As one research study puts it: It could be that the brain relies primarily on endogenous creatine synthesis until there is some sort of challenge to brain creatine status

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doi: 10.3390/cells10051056 56 SeetBTDikicIZhouMMPawsonT