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Description
Early signs and symptoms include rash sometimes like a bulls eye rash (Erythema migrans rash), fever, chills, headache, fatigue, muscle and joints aches and swollen lymph nodes

It has remarkable healing properties for tendons, ligaments, and other connective tissues

Redox Biol 28:101343 Warren RB, Mrowietz U, von Kiedrowski R, Niesmann J, Wilsmann-Theis D, Ghoreschi K, Zschocke I, Falk TM, Bldorn-Schlicht N, Reich K (2017) An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Hence, half-life extension may be achieved through either blocking of the metabolism or the increase in metabolically inert lipophilicity