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Recent studies have found that Src homolog and collagen homolog 3 (Shc3) are overexpressed in chemotherapy-resistant HCC and similarly activate this pathway, causing resistance to sorafenib and doxorubicin in HCC (168)

After 4 h incubation at room temperature, the sample concentration in the donor and acceptor wells were measured using a UV-Vis spectrophotometer (Beckman, DU640) set at the wavelength corresponding to the maximum absorption of each compound

IGF-1 A decreased serum levels of both IGFs were found to parallel progression of liver diseases, independently of their etiology (94,95)