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Yet the authors of the current study note: Further research is required to better understand the underlying mechanisms, since the efficacy of antioxidant supplementation in improving fertility outcomes is still a subject of debate. They therefore aimed to investigate the effectiveness of micronutrient combination on conventional sperm parameters, sperm DNA integrity, including sperm DNA fragmentation, and chromatin compaction, with the aim of then assessing the effect on ICSI/IVF outcome, embryonic quality, and pregnancy achievement

From inflammation to prostate Cancer: the role of Inflammasomes

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To ascertain which KGDD is driving the observed phenotype, we constructed a CRISPR knockout library of 64 KGDDs ( Table S1 ) and performed a dropout screen in the presence of olaparib ( Fig