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In addition to increased gene transcription, DEM and 4-hydroxy-2-nonenal treatments have also been found to stabilize the GCLC mRNA (Sekhar et al., 1997a

Acetaminophen Lipid peroxidation The hypothesis that LPO is the main cause of APAP hepatotoxicity was introduced by Wendel and coworkers 35 years ago, 38,5658 contrasting the previously established idea that protein binding of a reactive metabolite generated by cytochrome P450 is the key event in cell death

The magnitude of Chac1 downregulation exceeded that of canonical refeeding-responsive genes controlling hepatic glucose metabolism, such as the downregulation of G6pc or upregulation of Gck (Figure 6A), indicating robust transcriptional suppression of Chac1 during feeding

Oxidative stress accelerates skin aging, causing wrinkles, fine lines, and loss of elasticity