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The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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They are more common in women than in men and usually occur in fourth or fifth life decade.[28,29] Multiple labial and oral melanotic macules associated with linear streaks of nail pigmentation can be a symptom of Laugier-Hunziker syndrome.[30] Cases of multiple melanocytic macules have been reported in immunosuppressed patients.[31] It is not fully clarified whether dermoscopy of melanocytic macules varies depending on location between oral mucous membranes, lip, vulva and penile mucosa
